The belief that the people of God are called to be spiritual leaders is at the heart of our Presbyterian doctrine. This commitment manifests itself in a style of leadership that is unique in the worldwide church. This is embodied in the boards of the church: the Session and the Board of Deacons. The officers who serve on these boards have been identified for their gifts of leadership and a commitment to the life and ministry of this congregation and are elected to three-year terms by the congregation. Officers are ordained and installed to their offices when they begin their term of service.

First Presbyterian Glendale is a member of the Presbytery of Cincinnati, the Synod of the Covenant, and the Presbyterian Church (U.S.A.). As a congregation of the Presbyterian Church (U.S.A.), First Presbyterian Church is governed by the Constitution of the Presbyterian Church (USA). The Constitution is made up of Part I, the Book of Confessions; and Part II, the Book of Order. The Church is organized according to the denomination's Book of Order. Women and men are nominated and elected by the congregation to serve three year terms as ordained elders and deacons.

The Session, which is the governing body of the church, is made up of nine Elders (the translation of the Greek word presbyteros). The Session is responsible for the whole life and ministry of First Presbyterian Church.

Particular responsibilities outlined in the Book of Order include receiving new members; leading the congregation in mission; providing for worship and the administration of the sacraments—baptism and communion—offering educational programs, pastoral care, fellowship opportunities, and challenging the congregation in its stewardship of time, talent, and financial resources.

Several committees and the Board of Deacons carry out these responsibilities and report to the Session.

Deacons are responsible for the care of the congregation and outreach ministries. Each Sunday they can be found opening and closing the church buildings, greeting worshipers, ushering, and assisting with other worship responsibilities. Our Deacons also make visits to members who are sick, homebound, or hospitalized; offer assistance to those in the congregation who are in need; provide a meal ministry, an intercessory prayer ministry; and coordinate visits of the local Blood Mobile. The ministry of the Deacons is guided by the Book of Order and the church Session.